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The long-wavelength macromolecular crystallography beamline I23 at diamond is a unique facility for solving the crystallographic phase problem, using the small anomalous signals from sulphur or phosphorus which are present in native protein or RNA/DNA crystals. This will be of increased importance for projects where protein labelling to introduce anomalous scatterers is not feasible. In addition, the beamline's wavelength range will provide access to the M-edges of elements, with huge anomalous signals offering new opportunities for phasing large molecular complexes.
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