Speaker
Prof.
Sam BAYAT
(Univerisité de Grenoble Alpes)
Description
Elucidating the 3D structure and real-time function of the lung at small length scales in vivo, is one of the most challenging applications of synchrotron radiation in biomedical imaging. Dynamic measurements allowing the study of regional lung function, with methods using synchrotron radiation such as K-edge subtraction imaging are crucial for better understanding of phenomena such as gas transport and exchange, adverse effects of mechanical ventilation on the lung and strategies to prevent them, aerosol transport and deposition, among other applications. On the other hand, the coherence of synchrotron beams allows phase-contrast imaging of the poorly radiation-absorbing lung tissue, allowing enhancement of structural details. Real-time imaging of lung function is highly challenging at small length-scales. There is currently a trade-off between spatial and temporal resolutions, and both are difficult to achieve simultaneously. In vivo synchrotron radiation imaging also faces limitations due to radiation dose. Improvements in the available detector technology, allowing for significant gains in spatial resolution, efficiency, dynamic range, energy resolution as well as temporal resolution will be crucial for overcoming these limitations. Examples of in vivo synchrotron imaging in investigating models of lung diseases will be discussed.
